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Life Sciences

Vetting by Vetter Finds Chicago is Better

by Adam Bruns

Last fall, Vetter, a Ravensburg, Germany–based contract development and manufacturing organization (CDMO) that specializes in aseptic filling of syringe systems, cartridges and vials, announced it would be investing €300 million (US$335 million) in expanding and upgrading its manufacturing sites, mostly in and around its home base. In July, the company announced its intention to spend nearly that much in one US location: Des Plaines, Illinois, a northwest Chicago suburb in an area that first welcomed German immigrants by the thousands in the 1840s and 1850s, when German was the primary language in many area homes and churches.

Today the city is a human and cargo transportation hub, just five minutes from O’Hare International Airport, with two Interstates, numerous rail and bus commute options and five railroads all conspiring to fulfill the community’s slogan — “City of Destiny” — with destinations worth finding.

The 30,000-sq.-ft. (2,787-sq.-m.) Vetter Development Service (VDS) Chicago facility at Illinois Science + Technology Park in Skokie provides comprehensive clinical development and manufacturing resources from Preclinical to Phase II, including aseptic vial filling (inset). Until now, its smaller-scale work has served as a precursor to full-scale commercial filling contracts carried out at the company's German facilities.

The 30,000-sq.-ft. (2,787-sq.-m.) Vetter Development Service (VDS) Chicago facility at Illinois Science + Technology Park in Skokie provides comprehensive clinical development and manufacturing resources from Preclinical to Phase II, including aseptic vial filling (inset). Until now, its smaller-scale work has served as a precursor to full-scale commercial filling contracts carried out at the company’s German facilities.

Image courtesy of Vetter Pharma International GmbH

Vetter has signed an economic development agreement with the state, If the project passes muster with the city — and all indications are it will — Vetter is destined to invest $320 million and create at least 300 new jobs. That total would reach 400 to 500 if the company’s full 10-year plan of growth comes to pass.

Dr. Susanne Resatz, President, Vetter Development Services USA, Inc.

Dr. Susanne Resatz, President, Vetter Development Services USA, Inc.

Image courtesy of Vetter Pharma International GmbH

According to the City of Des Plaines Planning and Zoning Board agenda from its meeting on July 26th, the company plans to reuse two existing buildings on the 18-acre (7.3-hectare) property currently owned by the Salvation Army, and construct six new buildings, for a total of over 1.2 million sq. ft. (111,480 sq. m.) of building area. The company has requested that a parking ratio be established for pharmaceutical manufacturing and distribution, and requested planned-unit-development exceptions from the city’s maximum height restriction of 50 ft. (15.2 m.) for heights as great as 92 ft. (28 m.).

Vetter’s initial concept intends to offer its global customer base a US manufacturing opportunity for their market supply needs of commercialized drugs. If approved, the facility would be the second US manufacturing site of the company, paired with its existing US clinical development support service via a small-scale manufacturing facility located at Illinois Science + Technology Park in the nearby Village of Skokie. That complex employs about 70 of the company’s 3,600 employees globally. The purpose and scope of work between the two facilities would not be overlapping, the company stated, but complementary.

“We believe that this project represents a win-win scenario for the residents of Des Plaines and Vetter alike,” said Vetter Managing Director Peter Soelkner at a community meeting July 12, the same day that the Illinois Department of Commerce & Economic Opportunity and the Illinois Business and Economic Development Corporation (ILBEDC) announced the project. “For us, it would be the next step in our plan for continuous growth.”

(from l. to r.) Dr. Hitoshi Kuboniwa (Senior Vice President and General Manager of Pharmaceutical Technology Division at Chugai Pharmaceutical Co., Ltd.) and Peter Soelkner (Managing Director Vetter) share in the cutting of the ribbon signaling the opening of the Vetter Pharma International Japan K.K. office, its second in the Asia Pacific region.

(from l. to r.) Dr. Hitoshi Kuboniwa (Senior Vice President and General Manager of Pharmaceutical Technology Division at Chugai Pharmaceutical Co., Ltd.) and Peter Soelkner (Managing Director Vetter) share in the cutting of the ribbon signaling the opening of the Vetter Pharma International Japan K.K. office, its second in the Asia Pacific region.

Image courtesy of Vetter Pharma International GmbH

Vetter serves the top 10 pharmaceutical and biopharmaceutical companies, as well as small and midsized firms. One of them is AbbVie, headquartered not far away in North Chicago.

In 2015, Vetter increased sales by 10 percent, and supported nine customer drug approvals.

Peter Soelkner, Managing Director, Vetter Pharma International GmbH

Peter Soelkner, Managing Director, Vetter Pharma International GmbH

Image courtesy of Vetter Pharma International GmbH

ILBEDC CEO Jim Schultz and Department of Commerce Assistant Director Andria Winters met with Vetter executives during an April trip to Germany, which occurred following the state’s major presence at Hanover Messe, the world’s largest industrial fair.

“It was invaluable for Jim Schultz and Andria Winters to be able to meet directly with Vetter in Germany. It’s that kind of outreach and customer service that will set Illinois apart and help close deals,” said Department of Commerce Acting Director Sean McCarthy, who also gave credit to Skokie Mayor George Van Dusen, area utilities, the City of Des Plaines (whose economic development coordinator is Lauren Pruss) and Cook County for their support.

“Vetter will create hundreds of quality, high-skill jobs for Illinois residents, growing their presence in Illinois with lots of opportunity for future growth,” Illinois Governor Bruce Rauner said. “The collaboration between the State, the ILBEDC and our local partners was instrumental in attracting an investment of this scope and magnitude, which will reap economic benefits for Illinois for years to come.”

How It Happened

In an email interview, Vetter’s Peter Soelkner says customers have been asking for commercial manufacturing capability in both Europe and the US over the past couple of years.

“Based on that desire, combined with our long-term strategy for worldwide growth, we started searching for a potential property,” he says, noting the April visit in Germany with Illinois officials and the local support. But the search encompassed several US states. “The scales were tipped in favor of Des Plaines,” he says, for several reasons:

“Des Plaines offers a diverse business environment that is focused on success and growth,” he says. “We discovered a workforce in Greater Chicago that is committed to exceptional customer service. We have the feeling that business gets done here, and that the local workforce is well-educated and hardworking. And of course the high quality of life we have experienced so far is an important additional factor, being relevant for our customer relations and employees’ well-being.”

A successful approval and purchase process, Soelkner says, “supports our ‘ability to act’ preparations that put us in the position to offer our customer base greater flexibility in global manufacturing for the future. A facility would enable Vetter to further strengthen its strategic partnership approach with an increased global footprint.”

Attending the November 2014 ribbon-cutting ceremony for the opening of Vetter’s new representative office in Singapore were (from l. to r.) Thomas Otto (Managing Director Vetter), Kevin Lai (Executive Director, Biomedical Sciences EDB) and Peter Soelkner (Managing Director Vetter).

Attending the November 2014 ribbon-cutting ceremony for the opening of Vetter’s new representative office in Singapore were (from l. to r.) Thomas Otto (Managing Director Vetter), Kevin Lai (Executive Director, Biomedical Sciences EDB) and Peter Soelkner (Managing Director Vetter).

Image courtesy of Vetter Pharma International GmbH

Dr. Susanne Resatz, president of Vetter Development Services USA, Inc., in April was named to the board of directors for the German-American Chamber of Commerce of the Midwest, whose 14-state territory encompasses 1,400 German businesses and about one-quarter of the nation’s geographical area, population and GDP. Mark Tomkins, GACC-Midwest president and CEO, says, “We did support Vetter in their search and have had a close relationship since they set up their original US operation” in 2010. That was also the year Resatz arrived in Chicago from Germany. On her appointment to the GACC-Midwest board, she said the company’s two-country manufacturing approach aligned perfectly with the organization’s mission.

“Actively participating in organizations such as GACC Midwest helps Vetter broaden its horizon, with the goal of contributing to innovative and foresighted business and manufacturing processes,” she said. “As such, they are instrumental in helping to strengthen our relationships with customers, suppliers, and other stakeholders.”

Soelkner says GACC Midwest’s help “in identifying both the existing small-scale Skokie site and the proposed Des Plaines property for a potential new large-scale facility has been instrumental in assisting in our long-term expansion plans in the US and assisting in US-German trade.”

Punch List

The new investment is just the latest in a series of expansions and upgrades from Vetter, including in Skokie itself, where an additional staff shift for daily clinical manufacturing operations and the doubling of capacities for performing visual inspection and In-Process Control (IPC), among other additional offerings, were completed last June. The facility at that time passed audits and qualifications by as many as 30 companies, including nine of the top 20 leading (bio-)pharmaceutical companies.

A portion of Vetter's €300-million investment announced last September was directed to completion of the Ravensburg Vetter West facility expansion.

A portion of Vetter’s €300-million investment announced last September was directed to completion of the Ravensburg Vetter West facility expansion.

Image courtesy of Vetter Pharma International GmbH

“This performance has resulted in a wide-ranging customer base that includes not only those in the US, but also European companies based for example in the UK and Denmark, as well as Asian-headquartered companies such as in South Korea,” said the company last June. “Many of our customers have already returned for development work for a second, third, or even fourth molecule,” said Resatz.

Among the company’s other recent investments:

  • In January, a multi-functional building at its Schuetzenstrasse site in Ravensburg — part of the overall investment strategy announced last September — was completed on schedule after two years of construction and €29 million invested. The building was needed due to an increase in demand by customers for support in drug development, as well as the need for enhanced IT systems to meet future customer and regulatory requirements, the company said.
  • In March, at that same site, the company broke ground on a new €70-million ($79-million), 8,000-sq.-m. (86,000-sq.-ft.), seven-story building that will include a cleanroom, material preparation space, office space and a staff canteen with roof garden. It will begin operations in early 2019.
  • Elements of the €300-million investment strategy announced last September include the Ravensburg Vetter West center for visual inspection and logistics, expected to be fully operational by 2017; as well as expansion at the Ravensburg Vetter South production site.
  • In the third quarter of 2015, Vetter opened a new subsidiary in Tokyo to complement the Singapore operating branch created in 2014. “Vetter’s decision to expand their presence in the Asia Pacific region and to open their first office in Japan is a strong message of their commitment to service the needs of this important market,” said Dr. Hitoshi Kuboniwa, senior vice president and general manager of the Pharmaceutical Technology Division at Chugai Pharmaceutical Co., Ltd. The office is located in the rapidly growing Shinagawa district, directly across from Shinagawa rail station with direct access to the international Haneda and Narita airports.
A new 8,500-sq.m. (91,500-sq.-ft.), six-story building at Vetter's Schuetzenstrasse site in Ravensburg contains non-cGMP laboratories for development support, lab space for microbiological analysis, offices for Vetter Development Service and IT, and a data processing center.

A new 8,500-sq.m. (91,500-sq.-ft.), six-story building at Vetter’s Schuetzenstrasse site in Ravensburg contains non-cGMP laboratories for development support, lab space for microbiological analysis, offices for Vetter Development Service and IT, and a data processing center.

Image courtesy of Vetter Pharma International GmbH

As for future growth, Soelkner says, “Right now we are focusing our expansion plans on the US commercial site project.” But that doesn’t mean the wheels aren’t turning. As he puts it, employing a bit of medical terminology, no additional plans are yet “in a communicable stage.”